A single infusion of a gene-editing medicine may control inherited high LDL cholesterol
Research Highlights:
- In an interim report from the first study in people, a single infusion of a gene-editing therapy significantly reduced bad cholesterol (LDL-C) in people at high risk of early heart attack due to an inherited form of high cholesterol.
- Despite the availability […]
Reducing systolic blood pressure to less than 120 mm Hg reduced cardiovascular event risk
Research Highlights:
- In a 3-year trial, intensive treatment with antihypertensive medication to reduce systolic blood pressure, the top number, to less than 120 mm Hg reduced cardiovascular disease events among people at high-risk for cardiovascular disease by 12% compared to standard treatment with […]
NCAA athletes’ sudden cardiac death rate fell over 20 years, still higher in some athletes
This abstract is simultaneously published with a full manuscript in the AHA’s flagship journal Circulation.
Research Highlights:
- While the overall incidence of sudden cardiac death among National Collegiate Athletic Association athletes decreased over a 20-year study period through 2022, the rates of sudden cardiac […]
AI-phone app detected worsening heart failure based on changes in patients’ voices
Research Highlights:
- Analyzing a patient’s voice recorded daily on a smartphone, artificial intelligence technology detected increasing fluid in their lungs — a sign of worsening heart failure.
- In the trial of more than 400 adults with heart failure in Israel, the app predicted the […]
Artificial intelligence may speed heart attack diagnosis and treatment
Research Highlights:
- In a study of patients in a hospital in Taiwan, artificial intelligence technology paired with electrocardiogram testing reduced the time to diagnose and transfer people with heart attacks to the cardiac catheterization laboratory for treatment by about 10 minutes.
- The trial evaluated […]
One dose of experimental therapy reduced lipoprotein(a) more than 94% for nearly a year
Research Highlights:
- In this first trial in people, a single dose of a new therapeutic called lepodisiran reduced the harmful risk factor lipoprotein(a), or Lp(a), by up to 94%, with reductions lasting nearly a year.
- Lepodisiran is a small interfering RNA that lowers Lp(a) […]
New medication given every 1-3 months may slash stubborn high cholesterol
Research Highlights:
- While currently available PCSK9 inhibitor medications to lower cholesterol must be administered every few weeks by injection, a new, investigational PCSK9 inhibitor called recaticimab safely lowered bad cholesterol more than 50% when injected every 1-3 months, depending on dose.
- In the study, […]
Reducing sodium intake significantly lowered blood pressure in as little as one week
Research Highlights:
- A randomized trial comparing the effects of high-sodium and low-sodium diets on blood pressure in adults with normal blood pressure and high blood pressure found that following a low-sodium diet significantly lowered blood pressure in 70%-75% of participants in as little […]
Single dose of zilebesiran safely and effectively lowered blood pressure for six months
Research Highlights:
- The phase 2 study found that a single injection of the experimental medication zilebesiran safely and effectively lowered blood pressure in adults with mild-to-moderate hypertension for up to six months.
- Based on these results, zilebesiran has the potential to improve medication adherence […]
Leading cardiologists reveal new heart disease risk calculator
Statement Highlights:
- The new American Heart Association PREVENTTM risk calculator estimates the 10- and 30-year risk of total cardiovascular disease for people aged 30 years and older.
- The calculator estimates the risk of heart attack, stroke and — for the first time — heart […]